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KMID : 0359920100290010158
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Korean Journal of Nephrology
2010 Volume.29 No. 1 p.158 ~ p.161
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Glyphosate Induced Severe Tubulointerstitial Nephritis Requiring Hemodialysis
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Yoo Sun-Hong
Kim Byung-Soo
Lee Hye-Yun
Lee Ja-Young
Choi Jae-Ki
Kim Young-Soo
Yoon Sun-Ae
Choi Yeong-Jin
Kim Young-Ok
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Abstract
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This is the first case of glyphosate induced severe tubulointerstitial nephritis requiring hemodialysis without cardiovascular collapse. A 67-year-old man presented to the hospital 30 minutes after ingesting 90 mL of glyphosate herbicide. On arrival, his serum creatinine was 0.8 mg/dL and other laboratory findings including liver, cardiac, and muscle enzymes were all normal. Two days after admission, although his vital signs were stable, his creatinine abruptly increased to 8.2 mg/dL and oliguria developed. As a result, we started hemodialysis treatment and two weeks after initiation of hemodialysis, his renal function started to improve slowly. After discontinuation of hemodialysis, his renal function gradually recovered and serum creatinine level decreased to 1.6 mg/dL three weeks after admission.
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KEYWORD
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Glyphosate, Tubulointerstitial nephritis, Hemodialysis
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